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Similarly, Van Langendonckt et al (54) demonstrated iron deposits in endometriotic lesions, and experiments in mice revealed that injecting menstrual effluent containing red blood cells into mice led to substantial iron accumulation in lesions, whereas iron deposits were less prominent in injections containing only endometrial cells or serum

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After the completion of the study, it was noted that there appeared to be a significant reduction in the body weight of these murine models, including a reduction of excess body lipids

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The combined impact via mechanisms i , ii and/or iii on drug uptake, degradation, and efflux must be considered together, to determine the net effect on the steady-state intracellular drug concentration (see Fig

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To overcome these limitations, advanced drug delivery systems, particularly nanotechnology-based approaches, have emerged as promising solutions

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